Diabetic macular edema is a main reason for visual loss in diabetic patients. Until recent years, macular laser photocoagulation\r\nwas the only available therapy. The awareness that inflammation is an important factor in the pathogenetic process of DME gave\r\nreason for intravitreal treatment with corticosteroids. The introduction of anti-VEGF drugs brought a revolutionary change in the\r\ntreatment of DME. This paper will review the important clinical trials with an emphasis on combination therapies.
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